Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission

The Shank3 gene encodes a scaffolding protein that anchors multiple elements of the postsynaptic density at the synapse. Previous attempts to delete the Shank3 gene have not resulted in a complete loss of the predominant naturally occurring Shank3 isoforms. We have now characterized a homozygous Sha...

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Main Authors: Kouser, Mehreen, Speed, Haley E., Dewey, Colleen M., Reimers, Jeremy M., Widman, Allie J., Gupta, Natasha, Liu, Shunan, Jaramillo, Thomas C., Bangash, Muhammad, Xiao, Bo, Worley, Paul F., Powell, Craig M.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834052/
https://ncbi.nlm.nih.gov/pubmed/24259569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3017-13.2013
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