ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol

SCOPE: The objective of this study was to investigate the initial catabolic step of vitamin E and K metabolism, the ω-hydroxylation by human cytochrome P450 4F2 (CYP4F2). METHODS AND RESULTS: Tocopherol (T) metabolism was compared using rat liver slices incubated with deuterated (d(6))-RRR-α-T (d(6)...

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Hauptverfasser: Farley, Sherry M., Leonard, Scott W., Taylor, Alan W., Birringer, Marc, Edson, Katheryne Z., Rettie, Allan E., Traber, Maret G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833818/
https://ncbi.nlm.nih.gov/pubmed/23650179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201200797
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