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Saposin C Protects Glucocerebrosidase against α-Synuclein Inhibition
Mutations in GBA1, the gene for glucocerebrosidase (GCase), are genetic risk factors for Parkinson disease (PD). α-Synuclein (α-syn), a protein implicated in PD, interacts with GCase and efficiently inhibits enzyme activity. GCase deficiency causes the lysosomal storage disorder Gaucher disease (GD)...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3833811/ https://ncbi.nlm.nih.gov/pubmed/24070323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401191v |
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