Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein

BACKGROUND: Sporadic Creutzfeldt-Jakob disease is classified according to the genotype at polymorphic codon 129 (M or V) of the prion protein (PrP) gene and the type (1 or 2) of abnormal isoform of PrP (PrP(Sc)) in the brain. The most complicated entity in the current classification system is MV2, s...

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Autors principals: Kobayashi, Atsushi, Iwasaki, Yasushi, Otsuka, Hiroyuki, Yamada, Masahito, Yoshida, Mari, Matsuura, Yuichi, Mohri, Shirou, Kitamoto, Tetsuyuki
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833290/
https://ncbi.nlm.nih.gov/pubmed/24252157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-74
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