Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant

Arrestin-1 binds light-activated phosphorhodopsin and ensures timely signal shutoff. We show that high transgenic expression of an arrestin-1 mutant with enhanced rhodopsin binding and impaired oligomerization causes apoptotic rod death in mice. Dark rearing does not prevent mutant-induced cell deat...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Song, Xiufeng, Seo, Jungwon, Baameur, Faiza, Vishnivetskiy, Sergey A., Chen, Qiuyan, Kook, Seunghyi, Kim, Miyeon, Brooks, Evan K., Altenbach, Christian, Hong, Yuan, Hanson, Susan M., Palazzo, Maria C., Chen, Jeannie, Hubbell, Wayne L., Gurevich, Eugenia V., Gurevich, Vsevolod V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833262/
https://ncbi.nlm.nih.gov/pubmed/24012956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.08.022
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