Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant

Arrestin-1 binds light-activated phosphorhodopsin and ensures timely signal shutoff. We show that high transgenic expression of an arrestin-1 mutant with enhanced rhodopsin binding and impaired oligomerization causes apoptotic rod death in mice. Dark rearing does not prevent mutant-induced cell deat...

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Autors principals: Song, Xiufeng, Seo, Jungwon, Baameur, Faiza, Vishnivetskiy, Sergey A., Chen, Qiuyan, Kook, Seunghyi, Kim, Miyeon, Brooks, Evan K., Altenbach, Christian, Hong, Yuan, Hanson, Susan M., Palazzo, Maria C., Chen, Jeannie, Hubbell, Wayne L., Gurevich, Eugenia V., Gurevich, Vsevolod V.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833262/
https://ncbi.nlm.nih.gov/pubmed/24012956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.08.022
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