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Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant
Arrestin-1 binds light-activated phosphorhodopsin and ensures timely signal shutoff. We show that high transgenic expression of an arrestin-1 mutant with enhanced rhodopsin binding and impaired oligomerization causes apoptotic rod death in mice. Dark rearing does not prevent mutant-induced cell deat...
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| 主要な著者: | , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3833262/ https://ncbi.nlm.nih.gov/pubmed/24012956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.08.022 |
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