Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant

Arrestin-1 binds light-activated phosphorhodopsin and ensures timely signal shutoff. We show that high transgenic expression of an arrestin-1 mutant with enhanced rhodopsin binding and impaired oligomerization causes apoptotic rod death in mice. Dark rearing does not prevent mutant-induced cell deat...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Song, Xiufeng, Seo, Jungwon, Baameur, Faiza, Vishnivetskiy, Sergey A., Chen, Qiuyan, Kook, Seunghyi, Kim, Miyeon, Brooks, Evan K., Altenbach, Christian, Hong, Yuan, Hanson, Susan M., Palazzo, Maria C., Chen, Jeannie, Hubbell, Wayne L., Gurevich, Eugenia V., Gurevich, Vsevolod V.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833262/
https://ncbi.nlm.nih.gov/pubmed/24012956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.08.022
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares