Identification of regulatory structure and kinetic parameters of biochemical networks via mixed-integer dynamic optimization

BACKGROUND: Recovering the network topology and associated kinetic parameter values from time-series data are central topics in systems biology. Nevertheless, methods that simultaneously do both are few and lack generality. RESULTS: Here, we present a rigorous approach for simultaneously estimating...

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Hlavní autoři: Guillén-Gosálbez, Gonzalo, Miró, Antoni, Alves, Rui, Sorribas, Albert, Jiménez, Laureano
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832746/
https://ncbi.nlm.nih.gov/pubmed/24176044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-7-113
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