Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhances Induction of Apoptosis

Constitutively-activated tyrosine kinase mutants, such as BCR/ABL, FLT3-ITD, and Jak2-V617F, play important roles in pathogenesis of hematopoietic malignancies and in acquisition of therapy resistance. We previously found that hematopoietic cytokines enhance activation of the checkpoint kinase Chk1...

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Bibliographic Details
Main Authors: Kurosu, Tetsuya, Nagao, Toshikage, Wu, Nan, Oshikawa, Gaku, Miura, Osamu
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832535/
https://ncbi.nlm.nih.gov/pubmed/24260231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079478
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