PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells

Eitemau Tebyg

• Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhances Induction of Apoptosis
  gan: Kurosu, Tetsuya, et al.
  Cyhoeddwyd: (2013)
• DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3β.
  gan: Toshikage Nagao, et al.
  Cyhoeddwyd: (2011-01-01)
• c-Cbl and Cbl-b Ligases Mediate 17-Allylaminodemethoxygeldanamycin-induced Degradation of Autophosphorylated Flt3 Kinase with Internal Tandem Duplication through the Ubiquitin Proteasome Pathway
  gan: Oshikawa, Gaku, et al.
  Cyhoeddwyd: (2011)
• DNA Damage Stress and Inhibition of Jak2-V617F Cause Its Degradation and Synergistically Induce Apoptosis through Activation of GSK3β
  gan: Nagao, Toshikage, et al.
  Cyhoeddwyd: (2011)
• Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells
  gan: Umezawa, Yoshihiro, et al.
  Cyhoeddwyd: (2016)