c-Cbl and Cbl-b Ligases Mediate 17-Allylaminodemethoxygeldanamycin-induced Degradation of Autophosphorylated Flt3 Kinase with Internal Tandem Duplication through the Ubiquitin Proteasome Pathway

The class III receptor-tyrosine kinase Flt3 regulates normal hematopoiesis. An internal tandem duplication (ITD) in the juxtamembrane domain of Flt3 (Flt3-ITD) contributes to transformation and is associated with poor prognosis in acute myeloid leukemia. Here, we demonstrate that, as compared with w...

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Detalhes bibliográficos
Main Authors: Oshikawa, Gaku, Nagao, Toshikage, Wu, Nan, Kurosu, Tetsuya, Miura, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162385/
https://ncbi.nlm.nih.gov/pubmed/21768087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.232348
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