Novel Neuroprotective Function of Apical-Basal Polarity Gene Crumbs in Amyloid Beta 42 (Aβ42) Mediated Neurodegeneration

Alzheimer's disease (AD, OMIM: 104300), a progressive neurodegenerative disorder with no cure to date, is caused by the generation of amyloid-beta-42 (Aβ42) aggregates that trigger neuronal cell death by unknown mechanism(s). We have developed a transgenic Drosophila eye model where misexpressi...

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Detalhes bibliográficos
Main Authors: Steffensmeier, Andrew M., Tare, Meghana, Puli, Oorvashi Roy, Modi, Rohan, Nainaparampil, Jaison, Kango-Singh, Madhuri, Singh, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832507/
https://ncbi.nlm.nih.gov/pubmed/24260128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078717
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