A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration

Alzheimer's disease (AD, OMIM: 104300) is an age-related disorder that affects millions of people. One of the underlying causes of AD is generation of hydrophobic amyloid-beta 42 (Aβ42) peptides that accumulate to form amyloid plaques. These plaques induce oxidative stress and aberrant signalin...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Irwin, Madison, Tare, Meghana, Singh, Aditi, Puli, Oorvashi Roy, Gogia, Neha, Riccetti, Matthew, Deshpande, Prajakta, Kango-Singh, Madhuri, Singh, Amit
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082232/
https://ncbi.nlm.nih.gov/pubmed/32232042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00117
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