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Robust Expression of the Human Neonatal Fc Receptor in a Truncated Soluble Form and as a Full-Length Membrane-Bound Protein in Fusion with eGFP

Studies on the neonatal Fc receptor (FcRn) have revealed a multitude of important functions in mammals, including protection of IgG and serum albumin (SA) from lysosomal degradation. The pharmacokinetic behavior of therapeutic antibodies, IgG-Fc- and SA-containing drugs is therefore influenced by th...

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Autors principals: Seijsing, Johan, Lindborg, Malin, Löfblom, John, Uhlén, Mathias, Gräslund, Torbjörn
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832405/
https://ncbi.nlm.nih.gov/pubmed/24260574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081350
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