In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

The objective of this work was to characterize the in vitro (Plasmodium falciparum) and in vivo (Plasmodium berghei) activity profile of the recently discovered lead compound SSJ-183. The molecule showed in vitro a fast and strong inhibitory effect on growth of all P. falciparum blood stages, with a...

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Detalhes bibliográficos
Main Authors: Schleiferböck, Sarah, Scheurer, Christian, Ihara, Masataka, Itoh, Isamu, Bathurst, Ian, Burrows, Jeremy N, Fantauzzi, Pascal, Lotharius, Julie, Charman, Susan A, Morizzi, Julia, Shackleford, David M, White, Karen L, Brun, Reto, Wittlin, Sergio
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832383/
https://ncbi.nlm.nih.gov/pubmed/24255594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S51298
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