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Hypermutability and error catastrophe due to defects in ribonucleotide reductase
The enzyme ribonucleotide reductase (RNR) plays a critical role in the production of deoxynucleoside-5′-triphosphates (dNTPs), the building blocks for DNA synthesis and replication. The levels of the cellular dNTPs are tightly controlled, in large part through allosteric control of RNR. One importan...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3832021/ https://ncbi.nlm.nih.gov/pubmed/24167285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310849110 |
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