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Novel mutator mutants of E. coli nrdAB ribonucleotide reductase: insight into allosteric regulation and control of mutation rates
Ribonucleotide reductase (RNR) is the enzyme critically responsible for the production of the 5′-deoxynucleoside-triphosphates (dNTPs), the direct precursors for DNA synthesis. The dNTP levels are tightly controlled to permit high efficiency and fidelity of DNA synthesis. Much of this control occurs...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3340444/ https://ncbi.nlm.nih.gov/pubmed/22417940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.02.001 |
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