Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug

Cisplatin and other DNA-damaging chemotherapeutics are widely used to treat a broad spectrum of malignancies. However, their application is limited by both intrinsic and acquired chemoresistance. Most mutations that result from DNA damage are the consequence of error-prone translesion DNA synthesis,...

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Hlavní autoři: Xu, Xiaoyang, Xie, Kun, Zhang, Xue-Qing, Pridgen, Eric M., Park, Ga Young, Cui, Danica S., Shi, Jinjun, Wu, Jun, Kantoff, Philip W., Lippard, Stephen J., Langer, Robert, Walker, Graham C., Farokhzad, Omid C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832000/
https://ncbi.nlm.nih.gov/pubmed/24167294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303958110
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