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Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA–PEG nanoparticles

Cisplatin is used to treat a variety of tumors, but dose limiting toxicities or intrinsic and acquired resistance limit its application in many types of cancer including prostate. We report a unique strategy to deliver cisplatin to prostate cancer cells by constructing Pt(IV)-encapsulated prostate-s...

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Bibliografske podrobnosti
Main Authors: Dhar, Shanta, Gu, Frank X., Langer, Robert, Farokhzad, Omid C., Lippard, Stephen J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582270/
https://ncbi.nlm.nih.gov/pubmed/18978032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809154105
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