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α(V)β(3) Integrin-targeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrug

Targeted delivery of therapeutics to tumor neovasculature is potentially a powerful approach for selective cancer treatment. Integrins are heterodimeric transmembrane proteins involved in cell adhesion and cell signaling, and their expression is commonly upregulated in cancers and inflammatory disea...

詳細記述

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書誌詳細
主要な著者: Graf, Nora, Bielenberg, Diane R., Kolishetti, Nagesh, Muus, Christoph, Banyard, Jacqueline, Farokhzad, Omid C., Lippard, Stephen J.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358506/
https://ncbi.nlm.nih.gov/pubmed/22584163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn301148e
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