Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways

BACKGROUND: Neurocognitive impairments remain prevalent in HIV-1 infected individuals despite current antiretroviral therapies. It is increasingly becoming evident that astrocytes play a critical role in HIV-1 neuropathogenesis through the production of proinflammatory cytokines/chemokines. HIV-1 vi...

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Detalhes bibliográficos
Main Authors: Gangwani, Mohitkumar R, Noel, Richard J, Shah, Ankit, Rivera-Amill, Vanessa, Kumar, Anil
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831867/
https://ncbi.nlm.nih.gov/pubmed/24225433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-136
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