HIV-1 Nef Induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors

The prevalence of HIV-associated neurocognitive disorders (HAND) remains high in patients infected with HIV-1. The production of pro-inflammatory cytokines by astrocytes/microglia exposed to viral proteins is thought to be one of the mechanisms leading to HIV-1- mediated neurotoxicity. In the presen...

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Main Authors: Liu, Xun, Shah, Ankit, Gangwani, Mohitkumar R., Silverstein, Peter S., Fu, Mingui, Kumar, Anil
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963078/
https://ncbi.nlm.nih.gov/pubmed/24658403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04450
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