Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death

Excessive genome damage activates the apoptosis response. Protein kinase HIPK2 is a key regulator of DNA damage-induced apoptosis. Here, we deciphered the molecular mechanism of HIPK2 activation and show its relevance for DNA damage-induced apoptosis in cellulo and in vivo. HIPK2 autointeracts and s...

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Detalles Bibliográficos
Main Authors: Bitomsky, Nadja, Conrad, Elisa, Moritz, Christian, Polonio-Vallon, Tilman, Sombroek, Dirk, Schultheiss, Kathrin, Glas, Carolina, Greiner, Vera, Herbel, Christoph, Mantovani, Fiamma, del Sal, Giannino, Peri, Francesca, Hofmann, Thomas G.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
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PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831444/
https://ncbi.nlm.nih.gov/pubmed/24145406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310001110
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