Ligand-specific conformational change of the G-protein–coupled receptor ALX/FPR2 determines proresolving functional responses

Formyl-peptide receptor type 2 (FPR2), also called ALX (the lipoxin A4 receptor), conveys the proresolving properties of lipoxin A(4) and annexin A1 (AnxA1) and the proinflammatory signals elicited by serum amyloid protein A and cathelicidins, among others. We tested here the hypothesis that ALX mig...

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Detalhes bibliográficos
Main Authors: Cooray, Sadani N., Gobbetti, Thomas, Montero-Melendez, Trinidad, McArthur, Simon, Thompson, Dawn, Clark, Adrian J. L., Flower, Roderick J., Perretti, Mauro
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831442/
https://ncbi.nlm.nih.gov/pubmed/24108355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308253110
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