A 680 kb duplication at the FTO locus in a kindred with obesity and a distinct body fat distribution

Common intronic SNPs in the human fat mass and obesity associated (FTO) gene are strongly associated with body mass index (BMI). In mouse models, inactivation of the Fto gene results in a lean phenotype, whereas overexpression of Fto leads to increased food intake and obesity. The latter finding sug...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Davies, Robert W, Lau, Paulina, Naing, Thet, Nikpay, Majid, Doelle, Heather, Ellen Harper, Mary, Dent, Robert, McPherson, Ruth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831078/
https://ncbi.nlm.nih.gov/pubmed/23591406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2013.63
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