A 680 kb duplication at the FTO locus in a kindred with obesity and a distinct body fat distribution

Common intronic SNPs in the human fat mass and obesity associated (FTO) gene are strongly associated with body mass index (BMI). In mouse models, inactivation of the Fto gene results in a lean phenotype, whereas overexpression of Fto leads to increased food intake and obesity. The latter finding sug...

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Main Authors: Davies, Robert W, Lau, Paulina, Naing, Thet, Nikpay, Majid, Doelle, Heather, Ellen Harper, Mary, Dent, Robert, McPherson, Ruth
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831078/
https://ncbi.nlm.nih.gov/pubmed/23591406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2013.63
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