Combinational Targeting Offsets Antigen Escape and Enhances Effector Functions of Adoptively Transferred T Cells in Glioblastoma

Preclinical and early clinical studies have demonstrated that chimeric antigen receptor (CAR)-redirected T cells are highly promising in cancer therapy. We observed that targeting HER2 in a glioblastoma (GBM) cell line results in the emergence of HER2-null tumor cells that maintain the expression of...

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Detaylı Bibliyografya
Asıl Yazarlar: Hegde, Meenakshi, Corder, Amanda, Chow, Kevin KH, Mukherjee, Malini, Ashoori, Aidin, Kew, Yvonne, Zhang, Yi Jonathan, Baskin, David S, Merchant, Fatima A, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Wu, Meng Fen, Liu, Hao, Heslop, Helen E, Gottachalk, Stephen, Yvon, Eric, Ahmed, Nabil
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2013
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831041/
https://ncbi.nlm.nih.gov/pubmed/23939024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.185
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