Combinational Targeting Offsets Antigen Escape and Enhances Effector Functions of Adoptively Transferred T Cells in Glioblastoma

Preclinical and early clinical studies have demonstrated that chimeric antigen receptor (CAR)-redirected T cells are highly promising in cancer therapy. We observed that targeting HER2 in a glioblastoma (GBM) cell line results in the emergence of HER2-null tumor cells that maintain the expression of...

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Detalhes bibliográficos
Main Authors: Hegde, Meenakshi, Corder, Amanda, Chow, Kevin KH, Mukherjee, Malini, Ashoori, Aidin, Kew, Yvonne, Zhang, Yi Jonathan, Baskin, David S, Merchant, Fatima A, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Wu, Meng Fen, Liu, Hao, Heslop, Helen E, Gottachalk, Stephen, Yvon, Eric, Ahmed, Nabil
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831041/
https://ncbi.nlm.nih.gov/pubmed/23939024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.185
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