Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood

Individuals carrying (GGGGCC) expanded repeats in the C9orf72 gene represent a significant portion of patients suffering from amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Elucidating how these expanded repeats cause “c9FTD/ALS” has since become an important goal of the fiel...

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Bibliografski detalji
Glavni autori: Belzil, Veronique V., Bauer, Peter O., Prudencio, Mercedes, Gendron, Tania F., Stetler, Caroline T., Yan, Irene K., Pregent, Luc, Daughrity, Lillian, Baker, Matthew C., Rademakers, Rosa, Boylan, Kevin, Patel, Tushar C., Dickson, Dennis W., Petrucelli, Leonard
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2013
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Original Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3830740/
https://ncbi.nlm.nih.gov/pubmed/24166615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1199-1
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