Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

Based on existing data and previous work, a series of studies is proposed as a basis toward a pragmatic early step in transforming toxicity testing. These studies were assembled into a data-driven framework that invokes successive tiers of testing with margin of exposure (MOE) as the primary metric....

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Detalhes bibliográficos
Main Authors: Thomas, Russell S., Philbert, Martin A., Auerbach, Scott S., Wetmore, Barbara A., Devito, Michael J., Cote, Ila, Rowlands, J. Craig, Whelan, Maurice P., Hays, Sean M., Andersen, Melvin E., Meek, M. E. (Bette), Reiter, Lawrence W., Lambert, Jason C., Clewell, Harvey J., Stephens, Martin L., Zhao, Q. Jay, Wesselkamper, Scott C., Flowers, Lynn, Carney, Edward W., Pastoor, Timothy P., Petersen, Dan D., Yauk, Carole L., Nong, Andy
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829570/
https://ncbi.nlm.nih.gov/pubmed/23958734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft178
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