Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

Based on existing data and previous work, a series of studies is proposed as a basis toward a pragmatic early step in transforming toxicity testing. These studies were assembled into a data-driven framework that invokes successive tiers of testing with margin of exposure (MOE) as the primary metric....

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Main Authors: Thomas, Russell S., Philbert, Martin A., Auerbach, Scott S., Wetmore, Barbara A., Devito, Michael J., Cote, Ila, Rowlands, J. Craig, Whelan, Maurice P., Hays, Sean M., Andersen, Melvin E., Meek, M. E. (Bette), Reiter, Lawrence W., Lambert, Jason C., Clewell, Harvey J., Stephens, Martin L., Zhao, Q. Jay, Wesselkamper, Scott C., Flowers, Lynn, Carney, Edward W., Pastoor, Timothy P., Petersen, Dan D., Yauk, Carole L., Nong, Andy
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829570/
https://ncbi.nlm.nih.gov/pubmed/23958734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft178
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