Notch1 Receptor Regulates AKT Protein Activation Loop (Thr(308)) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells

Notch1 activating mutations occur in more than 50% of T-cell acute lymphoblastic leukemia (T-ALL) cases and increase expression of Notch1 target genes, some of which activate AKT. HES1 transcriptionally silences phosphatase and tensin homolog (PTEN), resulting in AKT activation, which is reversed by...

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Detalhes bibliográficos
Main Authors: Hales, Eric C., Orr, Steven M., Larson Gedman, Amanda, Taub, Jeffrey W., Matherly, Larry H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829367/
https://ncbi.nlm.nih.gov/pubmed/23788636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451625
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