Amino-terminal Domain Tetramer Organization and Structural Effects of Zinc Binding in the N-Methyl-d-aspartate (NMDA) Receptor

N-Methyl-d-aspartate (NMDA) receptors mediate excitatory neurotransmission in the mammalian central nervous system. An important feature of these receptors is their capacity for allosteric regulation by small molecules, such as zinc, which bind to their amino-terminal domain (ATD). Zinc inhibition t...

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Bibliographic Details
Main Authors: Sirrieh, Rita E., MacLean, David M., Jayaraman, Vasanthi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829342/
https://ncbi.nlm.nih.gov/pubmed/23792960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.482356
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