FOG2 Protein Down-regulation by Transforming Growth Factor-β1-induced MicroRNA-200b/c Leads to Akt Kinase Activation and Glomerular Mesangial Hypertrophy Related to Diabetic Nephropathy

Glomerular hypertrophy is a hallmark of diabetic nephropathy. Akt kinase activated by transforming growth factor-β1 (TGF-β) plays an important role in glomerular mesangial hypertrophy. However, the mechanisms of Akt activation by TGF-β are not fully understood. Recently, miR-200 and its target FOG2...

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Bibliografske podrobnosti
Main Authors: Park, Jung Tak, Kato, Mitsuo, Yuan, Hang, Castro, Nancy, Lanting, Linda, Wang, Mei, Natarajan, Rama
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829336/
https://ncbi.nlm.nih.gov/pubmed/23788640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.453043
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