Inositol 1,4,5-Trisphosphate (IP(3)) Receptor Up-regulation in Hypertension Is Associated with Sensitization of Ca(2+) Release and Vascular Smooth Muscle Contractility

Resistance arteries show accentuated responsiveness to vasoconstrictor agonists in hypertension, and this abnormality relies partly on enhanced Ca(2+) signaling in vascular smooth muscle (VSM). Although inositol 1,4,5-triphosphate receptors (IP(3)Rs) are abundant in VSM, their role in the molecular...

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Detalhes bibliográficos
Main Authors: Abou-Saleh, Haissam, Pathan, Asif R., Daalis, Arwa, Hubrack, Satanay, Abou-Jassoum, Hamda, Al-Naeimi, Hamda, Rusch, Nancy J., Machaca, Khaled
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829145/
https://ncbi.nlm.nih.gov/pubmed/24097979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.496802
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