Structure and function of Norrin in assembly and activation of a Frizzled 4–Lrp5/6 complex

Norrin is a cysteine-rich growth factor that is required for angiogenesis in the eye, ear, brain, and female reproductive organs. It functions as an atypical Wnt ligand by specifically binding to the Frizzled 4 (Fz4) receptor. Here we report the crystal structure of Norrin, which reveals a unique di...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ke, Jiyuan, Harikumar, Kaleeckal G., Erice, Clara, Chen, Chen, Gu, Xin, Wang, Liren, Parker, Naomi, Cheng, Zhihong, Xu, Wenqing, Williams, Bart O., Melcher, Karsten, Miller, Laurence J., Xu, H. Eric
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2013
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828517/
https://ncbi.nlm.nih.gov/pubmed/24186977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.228544.113
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