Norrin, Frizzled4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization

Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled4 (Fz4) receptor, Lrp5 co-receptor, or Norrin ligand cause retinal hypovascularization, but the role of Norrin/Fz4/Lrp signaling in vascular development has not been defined....

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Main Authors: Ye, Xin, Wang, Yanshu, Cahill, Hugh, Yu, Minzhong, Badea, Tudor C., Smallwood, Philip M., Peachey, Neal S., Nathans, Jeremy
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779707/
https://ncbi.nlm.nih.gov/pubmed/19837032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.07.047
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