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Norrin, Frizzled4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization
Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled4 (Fz4) receptor, Lrp5 co-receptor, or Norrin ligand cause retinal hypovascularization, but the role of Norrin/Fz4/Lrp signaling in vascular development has not been defined....
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2779707/ https://ncbi.nlm.nih.gov/pubmed/19837032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.07.047 |
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