Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity

Norrin/Frizzled4 (Fz4) signaling activates the canonical Wnt pathway to control retinal vascular development. Using genetically engineered mice, we show that precocious Norrin production leads to premature retinal vascular invasion and delayed Norrin production leads to characteristic defects in int...

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Hauptverfasser: Wang, Yanshu, Rattner, Amir, Zhou, Yulian, Williams, John, Smallwood, Philip M., Nathans, Jeremy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535266/
https://ncbi.nlm.nih.gov/pubmed/23217714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.10.042
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