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Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity
Norrin/Frizzled4 (Fz4) signaling activates the canonical Wnt pathway to control retinal vascular development. Using genetically engineered mice, we show that precocious Norrin production leads to premature retinal vascular invasion and delayed Norrin production leads to characteristic defects in int...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535266/ https://ncbi.nlm.nih.gov/pubmed/23217714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.10.042 |
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