Role of Glucuronidation for Hepatic Detoxification and Urinary Elimination of Toxic Bile Acids during Biliary Obstruction

Biliary obstruction, a severe cholestatic condition, results in a huge accumulation of toxic bile acids (BA) in the liver. Glucuronidation, a conjugation reaction, is thought to protect the liver by both reducing hepatic BA toxicity and increasing their urinary elimination. The present study evaluat...

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Main Authors: Perreault, Martin, Białek, Andrzej, Trottier, Jocelyn, Verreault, Mélanie, Caron, Patrick, Milkiewicz, Piotr, Barbier, Olivier
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828276/
https://ncbi.nlm.nih.gov/pubmed/24244729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080994
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