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Thioredoxin 1 is Essential for Sodium Sulfide-Mediated Cardioprotection in the Setting of Heart Failure

OBJECTIVE: The aim of this study was to determine if thioredoxin-1 (Trx1) mediates the cardioprotective effects of hydrogen sulfide (H(2)S) in a model of ischemic-induced heart failure. APPROACH/RESULTS: Mice with a cardiac-specific overexpression of a dominant negative mutant of Trx1 (Tg-DN-Trx1) a...

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Main Authors: Nicholson, Chad K., Lambert, Jonathan P., Molkentin, Jeffery D., Sadoshima, Junichi, Calvert, John W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827725/
https://ncbi.nlm.nih.gov/pubmed/23349187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300484
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