Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS)

A microwave-assisted, continuous-flow organic synthesis (MACOS) protocol for the synthesis of an isoindoline-annulat-ed, tricyclic sultam library, utilizing a Heck–aza-Michael (HaM) strategy, is reported. This sequence involves a Heck reaction on vi-nylsulfonamides with batch microwave heating follo...

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Autori principali: Ullah, Farman, Zang, Qin, Javed, Salim, Porubsky, Patrick, Neuenswander, Benjamin, Lushington, Gerald H., Hanson, Paul R., Organ, Michael G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827362/
https://ncbi.nlm.nih.gov/pubmed/24244052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0031-1289791
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