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A ΔclpB Mutant of Francisella tularensis Subspecies holarctica Strain, FSC200, Is a More Effective Live Vaccine than F. tularensis LVS in a Mouse Respiratory Challenge Model of Tularemia

Francisella tularensis subsp. tularensis is a highly virulent pathogen for humans especially if inhaled. Consequently, it is considered to be a potential biothreat agent. An experimental vaccine, F. tularensis live vaccine strain, derived from the less virulent subsp. holarctica, was developed more...

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Détails bibliographiques
Auteurs principaux: Golovliov, Igor, Twine, Susan M., Shen, Hua, Sjostedt, Anders, Conlan, Wayne
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827231/
https://ncbi.nlm.nih.gov/pubmed/24236032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078671
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