Heterozygous mutations in PALB2 cause DNA replication and damage response defects

Besides mutations in BRCA1/BRCA2, heterozygous defects in PALB2 are important in breast cancer predisposition. PALB2 heterozygosity increases the risk of malignancy about sixfold. PALB2 interacts with BRCA1 and BRCA2 to regulate homologous recombination and mediate DNA damage response. Here we show,...

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Hlavní autoři: Nikkilä, Jenni, Christin Parplys, Ann, Pylkäs, Katri, Bose, Muthiah, Huo, Yanying, Borgmann, Kerstin, Rapakko, Katrin, Nieminen, Pentti, Xia, Bing, Pospiech, Helmut, Winqvist, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826652/
https://ncbi.nlm.nih.gov/pubmed/24153426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3578
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