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Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients

Hereditary heterozygous mutations in a variety of DNA double-strand break (DSB) repair genes have been associated with increased breast cancer risk. In the Finnish population, PALB2 (partner and localizer of BRCA2) represents a major susceptibility gene for female breast cancer, and so far, only one...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Obermeier, K, Sachsenweger, J, Friedl, T W P, Pospiech, H, Winqvist, R, Wiesmüller, L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962030/
https://ncbi.nlm.nih.gov/pubmed/26640152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.448
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