Akt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency

Although PTEN/Akt signaling is frequently deregulated in human gastric cancers, the in vivo causal link between its dysregulation and gastric tumorigenesis has not been established. Here we show that inactivation of PTEN in mouse gastric epithelium initiates spontaneous carcinogenesis with complete...

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Detalhes bibliográficos
Main Authors: Guo, Shui-Long, Ye, Hui, Teng, Yan, Wang, You-Liang, Yang, Guan, Li, Xiu-Bin, Zhang, Chong, Yang, Xue, Yang, Zhong-Zhou, Yang, Xiao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826643/
https://ncbi.nlm.nih.gov/pubmed/24149576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3544
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