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Inhibition of NEDD8‐conjugation pathway by novel molecules: Potential approaches to anticancer therapy

Cancer cells can survive through the upregulation of cell cycle and the escape from apoptosis induced by numerous cellular stresses. In the normal cells, these biological cascades depend on scheduled proteolytic degradation of regulatory proteins via the ubiquitin–proteasome pathway. Therefore, inte...

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Autors principals: Tanaka, Tomoaki, Nakatani, Tatsuya, Kamitani, Tetsu
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826113/
https://ncbi.nlm.nih.gov/pubmed/22306028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2012.01.003
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