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Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.

The tet regulatory system in which doxycycline (dox) acts as an inducer of specifically engineered RNA polymerase II promoters was transferred into transgenic mice. Tight control and a broad range of regulation spanning up to five orders of magnitude were monitored dependent on the dox concentration...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kistner, A, Gossen, M, Zimmermann, F, Jerecic, J, Ullmer, C, Lübbert, H, Bujard, H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38261/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8855286/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.20.10933
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