Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity

The receptor tyrosine kinase Met and its ligand, the hepatocyte growth factor, are essential to embryonic development, whereas the deregulation of Met signaling is associated with tumorigenesis. While ligand-activated Met promotes survival, caspase-dependent generation of the p40 Met fragment leads...

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Main Authors: Lefebvre, J, Muharram, G, Leroy, C, Kherrouche, Z, Montagne, R, Ichim, G, Tauszig-Delamasure, S, Chotteau-Lelievre, A, Brenner, C, Mehlen, P, Tulasne, D
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824686/
https://ncbi.nlm.nih.gov/pubmed/24136235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.377
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