Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity

The receptor tyrosine kinase Met and its ligand, the hepatocyte growth factor, are essential to embryonic development, whereas the deregulation of Met signaling is associated with tumorigenesis. While ligand-activated Met promotes survival, caspase-dependent generation of the p40 Met fragment leads...

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Détails bibliographiques
Auteurs principaux: Lefebvre, J, Muharram, G, Leroy, C, Kherrouche, Z, Montagne, R, Ichim, G, Tauszig-Delamasure, S, Chotteau-Lelievre, A, Brenner, C, Mehlen, P, Tulasne, D
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824686/
https://ncbi.nlm.nih.gov/pubmed/24136235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.377
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