Calcineurin-mediated Dephosphorylation of eNOS at Serine 116 Affects eNOS Enzymatic Activity Indirectly by Facilitating c-Src Binding and Tyrosine 83 Phosphorylation

It has been shown previously that phosphorylation of the endothelial nitric oxide synthase (eNOS) at serine 116 (S116) under basal conditions suppresses eNOS enzymatic activity in endothelial cells. It has also been shown that vascular endothelial growth factor (VEGF) treatment of endothelial cells...

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Hauptverfasser: Ruan, Ling, Torres, Christina M., Buffett, Ryan J., Kennard, Simone, Fulton, David, Venema, Richard C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824616/
https://ncbi.nlm.nih.gov/pubmed/23727078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vph.2013.05.004
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